冷泉港实验室神经遗传学博士后

Position

Postdoctoral positions to study autism in genetic mouse models

Employer

Cold Spring Harbor Laboratory

Website

http://www.cshl.edu/public/staff.html

Location

Cold Spring Harbor, NY, 11724

Posted

January 19, 2009

Expires

March 20, 2009

Description

We are seeking up to four postdoctoral fellows interested in studying neural circuits in the mouse brain, with a specific focus on neural circuit disruptions in mouse models of autism.

Autism spectrum disorders (ASDs) are among the most heritable neuropsychiatric disorders, and many genes have been implicated in their etiology. Our research focuses on the identification and analysis of neural circuits that are disrupted in mouse models engineered to replicate human ASD-linked mutations. We combine both anatomical and functional methods, including high-throughput microscopy for whole mouse brain imaging, viral vector-based anatomical tracing, transgenic and knock-in “indicator” mouse lines for monitoring expression of activity-regulated genes, and both in vitro and in vivo two-photon imaging and electrophysiology. We collaborate closely with other CSHL teams focused on the problem of autism, including human geneticists uncovering disrupted loci in autism (Michael Wigler lab) and mouse geneticists engineering ASD mouse models (Alea Mills lab).

Candidates should be skilled experimentalists, highly motivated, and able to work in an interdisciplinary environment. Strong background in at least one of the following areas is required: mouse genetics, microscopy, molecular neurobiology, electrophysiology, and neuroanatomy. Both junior and senior postdoctoral positions are available.

Contact

If interested please e-mail your CV and contact information for three references to:

Pavel Osten
osten@cshl.edu

Associate Professor
Cold Spring Harbor Laboratory