卡罗林斯卡研究所神经再生博士后岗位
Position
A postdoctoral position to study salamander regeneration.
Employer
Karolinska Institute
Website
http://www.dbrm.se/dbrm/dbrmsite/faculty/simon.html
Location
Stockholm
Date Posted
January 08, 2009
Date Expires
March 31, 2009
Description
A postdoctoral position is available to study salamander regeneration.
Natural examples of regeneration, such as salamanders, may unravel novel strategies for cell replacement of damaged or lost tissues. We study regeneration mechanisms in an aquatic salamander, the newt, which has the widest repertoire of regenerative abilities among adult vertebrates
Our group has two main interests.
The first topic of our research is to understand how skeletal muscle contributes to new tissues during limb regeneration. We have identified a multipotent stem cell population in salamander skeletal muscle and we try to understand how these cells take part in limb regeneration. Salamander skeletal muscle may also undergo a unique dedifferentiation process during limb regeneration, and we aim to reveal the mechanisms underlying skeletal muscle dedifferentiation.
The second topic of our research is to reveal how brain regeneration can take place. Here we focus at neurogenesis/regeneration of adult dopaminergic neurons in a salamander model of Parkinsons disease. The role of GFAP expressing neural stem cells is currently in the focus of our research and we aim to understand how these are activated in the early phases of dopaminergic regeneration.
Primarily we are seeking candidates who are interested in neural regeneration and have strong background in neural biology. Candidates should have a PhD and be experienced in cell-, molecular-, and developmental biology. Training in animal research is of advantage.
Publications
Galliot, B., Tanaka, E.M., A. Simon. 2008. Regeneration and tissue repair. Cell Mol Life Sci, 65(1):3-7
Parish, C.L., Beljajeva, A., Arenas, E., A. Simon.
Midbrain Dopaminergic Neurogenesis and Behavioral Recovery in a Salamander Lesion-Induced Regeneration Model.
Development, 2007, 134(15):2881-7
A. Simon and J. Frisén, 2007, From stem cell to progenitor and back again. Cell, 128, 825-826
Loof, S, Straube, W, Drechsel, D, Tanaka, EM, Simon, A.
Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor.
Cell Cycle, 2007, 6(9):1096-101
Morrison JI, Loof S, He P, Alestrom P, Collas P, Simon A.
Targeted gene delivery to differentiated skeletal muscle: A tool to study dedifferentiation.
Dev Dyn. 2007 Feb;236(2):481-8.
Morrison, JI, Lööf, S, He, P, Simon A.
Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population.
J Cell Biol. 2006 Jan 30;172(3):433-40.