伊利诺伊州立大学多发性硬化病研究博士后岗位
来源：丁香人才网
日期：2008-05-21
Institution
University of Illinois
Position
Post doctoral fellow
Location
Downtown Chicago, IL
Date Posted
May 19th 2008
Date Expires
July 18th 2008
Tags
multiple sclerosis, chicago, inflammation, neuroscience, and il
Description
A post doctoral position is available to study the effects of inducing aheat shock response (HSR) on the development of disease in a mouse model(EAE) of multiple sclerosis. This is an NIH funded project toinvestigate the molecular mechanisms by which a HSR isanti-inflammatory, inhibits Tcell responses, is neuroprotective, andmodifies adult neurogenesis (J. Neurochem, 99, p. 1351-62, 2006; J.Neurosci Res 67, 461-70, 2002; J. Neurochem 85, 387-398, 2003). Studieswill make use of novel small molecular weight compounds to inhibitHSP90, and will explore the relative importance of client proteindegradation versus induction of a HSR. The candidate should haveexperience in the EAE model or in analysis of Tcell activation, andknowledge of basic brain histological and Immunostaining methods. Otherprojects in the Feinstein lab include studies of stress responses andadrenergic signaling in the EAE model, in transgenic mouse models of AD,and in primary glial and neuronal cultures.
Contact
Please send cv, description of research background, and letters ofreference to: Dr Douglas L Feinstein, Department of Anesthesiology, 835South Wolcott Street, MC513, Room E720, Chicago, IL 60612. email: dlfeins@uic.edu
The University of Illinois is an equal opportunity institution.
University of Illinois
Position
Post doctoral fellow
Location
Downtown Chicago, IL
Date Posted
May 19th 2008
Date Expires
July 18th 2008
Tags
multiple sclerosis, chicago, inflammation, neuroscience, and il
Description
A post doctoral position is available to study the effects of inducing aheat shock response (HSR) on the development of disease in a mouse model(EAE) of multiple sclerosis. This is an NIH funded project toinvestigate the molecular mechanisms by which a HSR isanti-inflammatory, inhibits Tcell responses, is neuroprotective, andmodifies adult neurogenesis (J. Neurochem, 99, p. 1351-62, 2006; J.Neurosci Res 67, 461-70, 2002; J. Neurochem 85, 387-398, 2003). Studieswill make use of novel small molecular weight compounds to inhibitHSP90, and will explore the relative importance of client proteindegradation versus induction of a HSR. The candidate should haveexperience in the EAE model or in analysis of Tcell activation, andknowledge of basic brain histological and Immunostaining methods. Otherprojects in the Feinstein lab include studies of stress responses andadrenergic signaling in the EAE model, in transgenic mouse models of AD,and in primary glial and neuronal cultures.
Contact
Please send cv, description of research background, and letters ofreference to: Dr Douglas L Feinstein, Department of Anesthesiology, 835South Wolcott Street, MC513, Room E720, Chicago, IL 60612. email: dlfeins@uic.edu
The University of Illinois is an equal opportunity institution.
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