得克萨斯州MD安德森肿瘤中心肿瘤转移研究博士后岗位
来源：丁香人才网
日期：2008-04-18
Institution
M. D. Anderson Cancer Center (http://www.mdanderson.org)
Position
Postdoctoral Research Fellow
Location
Houston, TX
Date Posted
April 16th 2008
Date Expires
June 15th 2008
Tags
postdoc, stem cells, cancer, emt, invasion, metastasis, cancer stemcells, epithelial mesenchymal transition, houston, tx, and usa
Description
The transformation of epithelial cells results in the formation of alocalized tumor. Some tumors become invasive and metastatic bytransiently activating embryonic program called epithelial mesenchymaltransition (EMT). Tumor cells that underwent EMT appear mesenchymal andbecome highly migratory and invasive. Several transcription factorsregulate EMT process including FOXC2, Twist, Snail, Goosecoid, Slug& SIP1. We found that inhibiting the expression of FOXC2 (Mani &Yang et al., PNAS, 2007) or Twist (Yang & Mani et al., Cell, 2004)in highly metastatic cells completely suppressed their metastaticability. Strikingly, these cells that underwent EMT also exhibitproperties of stem cells (Mani et al, Cell, in press). These findingsillustrate the importance of EMT and the transcription factors thatregulate EMT in cancer metastasis.
Our laboratory is interested in understanding the role that a number ofthese transcription factors play during cancer metastases. We use avariety of in vitro and in vivo tumor models and tissue specificinducible transgenic mouse models to study the role of EMT in cancer metastasis.
We are looking for self-motivated individuals to study the role ofnumber of these transcription factors during the cancer metastases.Bright and independent individuals with a Ph.D. in any area ofbiomedical science are encouraged to apply. In addition, experience incancer cell biology, developmental biology or stem cells will be a pluspoint. A competitive salary and an excellent work environment will beprovided.
Contact
Please send CV and contact information for three references to thefollowing address:
Marie Everett
Sr. Administrative Assistant
“On behalf of” Dr. Sendurai Mani
Assistant Professor
Department of Molecular Pathology
M. D. Anderson Cancer Center
Houston, TX 77054
e-mail: mihernandez@mdanderson.org
M. D. Anderson Cancer Center (http://www.mdanderson.org)
Position
Postdoctoral Research Fellow
Location
Houston, TX
Date Posted
April 16th 2008
Date Expires
June 15th 2008
Tags
postdoc, stem cells, cancer, emt, invasion, metastasis, cancer stemcells, epithelial mesenchymal transition, houston, tx, and usa
Description
The transformation of epithelial cells results in the formation of alocalized tumor. Some tumors become invasive and metastatic bytransiently activating embryonic program called epithelial mesenchymaltransition (EMT). Tumor cells that underwent EMT appear mesenchymal andbecome highly migratory and invasive. Several transcription factorsregulate EMT process including FOXC2, Twist, Snail, Goosecoid, Slug& SIP1. We found that inhibiting the expression of FOXC2 (Mani &Yang et al., PNAS, 2007) or Twist (Yang & Mani et al., Cell, 2004)in highly metastatic cells completely suppressed their metastaticability. Strikingly, these cells that underwent EMT also exhibitproperties of stem cells (Mani et al, Cell, in press). These findingsillustrate the importance of EMT and the transcription factors thatregulate EMT in cancer metastasis.
Our laboratory is interested in understanding the role that a number ofthese transcription factors play during cancer metastases. We use avariety of in vitro and in vivo tumor models and tissue specificinducible transgenic mouse models to study the role of EMT in cancer metastasis.
We are looking for self-motivated individuals to study the role ofnumber of these transcription factors during the cancer metastases.Bright and independent individuals with a Ph.D. in any area ofbiomedical science are encouraged to apply. In addition, experience incancer cell biology, developmental biology or stem cells will be a pluspoint. A competitive salary and an excellent work environment will beprovided.
Contact
Please send CV and contact information for three references to thefollowing address:
Marie Everett
Sr. Administrative Assistant
“On behalf of” Dr. Sendurai Mani
Assistant Professor
Department of Molecular Pathology
M. D. Anderson Cancer Center
Houston, TX 77054
e-mail: mihernandez@mdanderson.org
[作者：jurgen 编辑：]