法国巴黎巴斯德研究所血细胞生成研究博士后岗位
来源：丁香人才网
日期：2008-04-08
Institution
Unit of lymphocyte development, Ana Cumano/Rachel Golub
Position
Post-doctoral position in Hematopoiesis, Institut Pasteur, Paris, France
Location
Paris, france, 75015
Date Posted
April 7th 2008
Date Expires
October 31th 2008
Tags
hematopoiesis, immunology, institut pasteur, paris, france, hsc, andpost doctoral position
Description
Project
The aim of the project will be to study the interactions ofhematopoietic progenitors and the niches implicated in HSCnon-maintenance and myeloid differentiation in the fetal murine spleen.Fetal spleen stromal cell lines were derived in the laboratory as amodel system to test molecules before application to fresh stroma. Theanalysis will focus on TGFb superfamily members. In parallel, thecontribution of these molecules to human myelofibrosis myeloidmetaplasia will be analyzed.
Requirements
Candidates that hold the equivalent of a PhD in Immunology, Biology, orLife Sciences are welcome to apply. Candidates should have a backgroundin immunology or hematopoiesis and previous experience with animal work,molecular and cellular biology are required. Experience in humanhematopoiesis and clinical studies will be considered as an advantage.
Starting date: as soon as possible, initial contract for 1 year, withthe possibility for extension.
Recent publications of the Unit related to the subject:
Mark FR Vondenhoff, Guillaume E Desanti, Tom Cupedo, Julien Y Bertrand,Ana Cumano, Georg Kraal, Reina Mebius, and Rachel Golub. “Separation ofsplenic red and white pulp occurs before birth in a LT independentmanner” .” J Leukoc Biol. 2008, in press.
Desanti GE, Cumano A, Golub R. “Identification of CD4int progenitors inmouse fetal spleen, a source of resident lymphoid cells.” J Leukoc Biol.2008, in press.
Cumano A, Godin I.” Ontogeny of the hematopoietic system.” Annu RevImmunol. 2007; 25:745-85. Review.
Desanti G.E., Bertrand J.Y., and Golub R. Fetal Spleen Development, theRide toward Multiple Functions. (2007) Functional Development andEmbryology 1(1), 78-90. Invited Review
Bertrand JY, Desanti GE, Lo-Man R, Leclerc C, Cumano A, Golub R. “Fetalspleen stroma drives macrophage commitment.” Development. 2006 133(18):3619-28.
Bertrand JY, Giroux S, Golub R, Klaine M, Jalil A, Boucontet L, Godin I,Cumano A. “Characterization of purified intraembryonic hematopoieticstem cells as a tool to define their site of origin.” PNAS USA. 2005 102(1):134-9.
Contact
Application and CV should be sent to Dr. R. Golub, rgolub@pasteur.fr
Unité du développement des Lymphocytes
Institut Pasteur, INSERM U668
25 Rue du Dr Roux 75724 Paris Cedex 15
Tel/fax: (33) 1 45 68 87 66/(33) 1 45 68 89 21
Unit of lymphocyte development, Ana Cumano/Rachel Golub
Position
Post-doctoral position in Hematopoiesis, Institut Pasteur, Paris, France
Location
Paris, france, 75015
Date Posted
April 7th 2008
Date Expires
October 31th 2008
Tags
hematopoiesis, immunology, institut pasteur, paris, france, hsc, andpost doctoral position
Description
Project
The aim of the project will be to study the interactions ofhematopoietic progenitors and the niches implicated in HSCnon-maintenance and myeloid differentiation in the fetal murine spleen.Fetal spleen stromal cell lines were derived in the laboratory as amodel system to test molecules before application to fresh stroma. Theanalysis will focus on TGFb superfamily members. In parallel, thecontribution of these molecules to human myelofibrosis myeloidmetaplasia will be analyzed.
Requirements
Candidates that hold the equivalent of a PhD in Immunology, Biology, orLife Sciences are welcome to apply. Candidates should have a backgroundin immunology or hematopoiesis and previous experience with animal work,molecular and cellular biology are required. Experience in humanhematopoiesis and clinical studies will be considered as an advantage.
Starting date: as soon as possible, initial contract for 1 year, withthe possibility for extension.
Recent publications of the Unit related to the subject:
Mark FR Vondenhoff, Guillaume E Desanti, Tom Cupedo, Julien Y Bertrand,Ana Cumano, Georg Kraal, Reina Mebius, and Rachel Golub. “Separation ofsplenic red and white pulp occurs before birth in a LT independentmanner” .” J Leukoc Biol. 2008, in press.
Desanti GE, Cumano A, Golub R. “Identification of CD4int progenitors inmouse fetal spleen, a source of resident lymphoid cells.” J Leukoc Biol.2008, in press.
Cumano A, Godin I.” Ontogeny of the hematopoietic system.” Annu RevImmunol. 2007; 25:745-85. Review.
Desanti G.E., Bertrand J.Y., and Golub R. Fetal Spleen Development, theRide toward Multiple Functions. (2007) Functional Development andEmbryology 1(1), 78-90. Invited Review
Bertrand JY, Desanti GE, Lo-Man R, Leclerc C, Cumano A, Golub R. “Fetalspleen stroma drives macrophage commitment.” Development. 2006 133(18):3619-28.
Bertrand JY, Giroux S, Golub R, Klaine M, Jalil A, Boucontet L, Godin I,Cumano A. “Characterization of purified intraembryonic hematopoieticstem cells as a tool to define their site of origin.” PNAS USA. 2005 102(1):134-9.
Contact
Application and CV should be sent to Dr. R. Golub, rgolub@pasteur.fr
Unité du développement des Lymphocytes
Institut Pasteur, INSERM U668
25 Rue du Dr Roux 75724 Paris Cedex 15
Tel/fax: (33) 1 45 68 87 66/(33) 1 45 68 89 21
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