英国Bristol大学阿片受体研究博士后岗位
来源：丁香人才网
日期：2008-03-27
Institution
University of Bristol, UK (http://www.bris.ac.uk)
Position
Postdoctoral Research Assistant
Location
Bristol, UK
Dater Posted
March 26th 2008
Date Expires
April 2nd 2008
Tags
physiology, pharmacology, postdoctoral research assistant, bristol, anduk
Description
Postdoctoral Research Assistant (ref. 13847)
Based in the Department of Physiology and Pharmacology, working in thelaboratories of Dr Eamonn Kelly and Professor Graeme Henderson, the aimof this Wellcome Trust project is to study agonist-specific mechanismsof mu-opioid receptor (MOPr) desensitisation.
You will investigate the phenomenon of functional selectivity at MOPr.It is now thought that different agonists can induce different activeconformational states of G protein-coupled receptors such as MOPr. Thisphenomenon, termed functional selectivity, may also extend to theprocess of MOPr desensitization with different agonists inducingdesensitization by different molecular mechanisms. This may explain thedifferential ability of MOPr agonists such as morphine and DAMGO toinduce tolerance to the euphoric and analgesic effects of these drugs inthe intact organism. You will use a range of biochemical, molecular andpharmacological techniques to study the molecular basis for thesedifferences. Given the timescale needed for completion of the project,you should already possess substantial experience in the relevanttechniques. You should also have or be working towards a PhD inmolecular neuropharmacology.
Further information can be found at:
http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=56
Contact
If successful, you may be appointed either on a fixed term or apermanent contract depending on the extent of your previous relevantresearch experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
University of Bristol, UK (http://www.bris.ac.uk)
Position
Postdoctoral Research Assistant
Location
Bristol, UK
Dater Posted
March 26th 2008
Date Expires
April 2nd 2008
Tags
physiology, pharmacology, postdoctoral research assistant, bristol, anduk
Description
Postdoctoral Research Assistant (ref. 13847)
Based in the Department of Physiology and Pharmacology, working in thelaboratories of Dr Eamonn Kelly and Professor Graeme Henderson, the aimof this Wellcome Trust project is to study agonist-specific mechanismsof mu-opioid receptor (MOPr) desensitisation.
You will investigate the phenomenon of functional selectivity at MOPr.It is now thought that different agonists can induce different activeconformational states of G protein-coupled receptors such as MOPr. Thisphenomenon, termed functional selectivity, may also extend to theprocess of MOPr desensitization with different agonists inducingdesensitization by different molecular mechanisms. This may explain thedifferential ability of MOPr agonists such as morphine and DAMGO toinduce tolerance to the euphoric and analgesic effects of these drugs inthe intact organism. You will use a range of biochemical, molecular andpharmacological techniques to study the molecular basis for thesedifferences. Given the timescale needed for completion of the project,you should already possess substantial experience in the relevanttechniques. You should also have or be working towards a PhD inmolecular neuropharmacology.
Further information can be found at:
http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=56
Contact
If successful, you may be appointed either on a fixed term or apermanent contract depending on the extent of your previous relevantresearch experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
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