美国哈佛大学公共卫生学院计算生物学及基因组学博士后岗位

The Huttenhower lab in theBiostatistics Department of the Harvard School of Public Health isseeking to fill two postdoctoral research positions. The firstsuccessful candidate will be responsible for funded research in themicrobiology of the built environment, specifically the interaction,transmissibility, and identifiability of the human microbiome in theBoston mass transit system. The second fellow will be appointed at theBroad Institute to study the gut microbiome in inflammatory boweldisease as part of an ongoing collaboration with the laboratory of Dr.Ramnik Xavier. The Huttenhower lab is broadly engaged in studies of thehuman microbiome in health and disease, with a focus on computationalmethods to characterize biomolecular functions within these microbialcommunities and their interactions with host immunity, genetics, andenvironment.

For the first position, we specifically seek to determine A) therelationship between the human microbiome and surfaces in an enclosedsetting trafficked by millions of individuals (i.e. mass transit); B)the degree to which such an environment serves to transmit microbialcommunities among individuals; and C) the functional reservoir ofmicrobial genes transmitted in this manner (e.g. antibiotic resistance).The second position will investigate the mechanisms of host-microbiomeinteractions in inflammatory bowel disease, based on pathways implicatedboth in the human host (through previous genetic association work) andin the microbiome (from recent functional screens). The candidates forthese projects will be responsible both for experimental aspects (e.g.sample collection on the Boston subway) and for computational methodsdevelopment to enable subsequent analysis. They should be broadlyconversant with bioinformatic techniques for genomic data analysis andwill collaborate closely with software developers for methodsimplementation and with experimental team members for validation ofcomputational results.

The first position will be located within the Department ofBiostatistics at the Harvard School of Public Health; the second at theBroad Institute. The Huttenhower group works closely with the BroadInstitute itself, the Human Microbiome Project, the Dana-Farber CancerInstitute, and the broader Boston biomedical and life sciencescommunities, resulting in a rich environment for quantitative,computational, and laboratory collaborations.

Qualifications:

Doctoral degree in Computer Science, Bioinformatics, Biostatistics,Biology, or a related field; proficiency in one or more statistical orscripting languages appropriate for scalable data analysis; comfort andexperience with programming for biological data analysis; familiaritywith functional genetic and/or genomic data, as indicated by publicationrecord; ability to communicate scientific material and collaborate well.