密歇根大学膜转运蛋白研究博士后岗位
来源：丁香人才网
日期：2008-02-25
Institution
University of Michigan, Department of Biomedical Engineering andDepartment of Chemical Engineering
Position
Postdoctoral Research Fellow / Lab Manager(http://biomembrane.engin.umic...)
Location
Ann Arbor, Michigan, USA
Date Posted
February 22th 2008
Date Expires
December 31, 2008
Tags
postdoctoral research fellow, lab manager, ann arbor, michigan, and usa
Description
The Biomembrane Lab at the University of Michigan, Department ofBiomedical Engineering and Department of Chemical Engineering, isseeking a highly qualified protein biochemist or biophysicist for apostdoctoral position in the area of membrane transport proteins.
The mission of the Biomembrane Lab is to develop biophysical assays thatincrease the understanding of membrane transport proteins. Ultimately,the lab is using the ensuing insight to explore novel strategies forinterfering with altered membrane transport in the context of diseasessuch as multiple sclerosis, Alzheimer’s disease, and cancer. The primaryfocus of this postdoctoral position, which is part of a team effort, isto carry out functional transport assays on multidrug resistance (MDR)proteins. These MDR transporters contribute to resistance tochemotherapy in cancer treatment and their exact mechanisms of functionare largely unknown. The proposed research project will combine singlemolecule optical detection techniques such as fluorescence correlationspectroscopy (FCS) with chip-based electrophysiological recordingsthrough planar lipid bilayers (BLM) to reveal transport rates ofchemotherapeutic agents under well-controlled conditions in the presenceand absence of agents that may modulate transport function. In analogyto patch clamp recordings of single ion channels, we ultimately aim toresolve transport rates of individual MDR transporters. This project isfunded by the National Institute of Health (NIH); the position isavailable immediately and will be renewed annually based on research progress.
Qualifications: Applicants should have a Ph.D. degree in biochemistry,biological chemistry, biophysics or a related field. Ideally, he or sheshould have worked with membrane proteins, be familiar with proteinreconstitution techniques, and have previous experience with proteinactivity assays. Previous hands-on experience with electrophysiology(patch clamp or planar lipid bilayer, BLM) is highly desirable.Knowledge in surface chemistry and fluorescence microscopy would behelpful. Ideally, the applicant should be proficient in cell culture,preparation of membrane fragments, ultracentrifugation, gelelectrophoresis, Western blotting. These experiences should be reflectedin a strong publication record. The applicant should have excellentwritten and verbal communication skills in English, ability to workindependently and collaboratively with graduate students and otherpostdoctoral fellows, plan and perform experiments, analyze data,communicate results in scientific publications, and enjoy learning newtechniques. Previous experience in supervising students, guidingresearch projects, contributing to grant applications, and preparingeffective graphics are advantageous. A competitive salary will beoffered for applicants with advanced qualifications; this position couldalso be conceived long-term as a lab manager.
Contact
Interested candidates should send a cover letter, resume, and the namesand contact information (affiliation, mailing address, e-mail, and phonenumber) of three professional references preferably via e-mail toMichael Mayer (mimayer@umich.edu)
The University of Michigan is a premier research institution. TheDepartments of Biomedical Engineering and of Chemical Engineering haveleading programs in the country within a stimulating, multidisciplinary,and collaborative research environment. The Biomembrane Lab is housed inthe newly-constructed Lurie Biomedical Engineering Building withstate-of-the-art facilities and brand new research equipment.
University of Michigan, Department of Biomedical Engineering andDepartment of Chemical Engineering
Position
Postdoctoral Research Fellow / Lab Manager(http://biomembrane.engin.umic...)
Location
Ann Arbor, Michigan, USA
Date Posted
February 22th 2008
Date Expires
December 31, 2008
Tags
postdoctoral research fellow, lab manager, ann arbor, michigan, and usa
Description
The Biomembrane Lab at the University of Michigan, Department ofBiomedical Engineering and Department of Chemical Engineering, isseeking a highly qualified protein biochemist or biophysicist for apostdoctoral position in the area of membrane transport proteins.
The mission of the Biomembrane Lab is to develop biophysical assays thatincrease the understanding of membrane transport proteins. Ultimately,the lab is using the ensuing insight to explore novel strategies forinterfering with altered membrane transport in the context of diseasessuch as multiple sclerosis, Alzheimer’s disease, and cancer. The primaryfocus of this postdoctoral position, which is part of a team effort, isto carry out functional transport assays on multidrug resistance (MDR)proteins. These MDR transporters contribute to resistance tochemotherapy in cancer treatment and their exact mechanisms of functionare largely unknown. The proposed research project will combine singlemolecule optical detection techniques such as fluorescence correlationspectroscopy (FCS) with chip-based electrophysiological recordingsthrough planar lipid bilayers (BLM) to reveal transport rates ofchemotherapeutic agents under well-controlled conditions in the presenceand absence of agents that may modulate transport function. In analogyto patch clamp recordings of single ion channels, we ultimately aim toresolve transport rates of individual MDR transporters. This project isfunded by the National Institute of Health (NIH); the position isavailable immediately and will be renewed annually based on research progress.
Qualifications: Applicants should have a Ph.D. degree in biochemistry,biological chemistry, biophysics or a related field. Ideally, he or sheshould have worked with membrane proteins, be familiar with proteinreconstitution techniques, and have previous experience with proteinactivity assays. Previous hands-on experience with electrophysiology(patch clamp or planar lipid bilayer, BLM) is highly desirable.Knowledge in surface chemistry and fluorescence microscopy would behelpful. Ideally, the applicant should be proficient in cell culture,preparation of membrane fragments, ultracentrifugation, gelelectrophoresis, Western blotting. These experiences should be reflectedin a strong publication record. The applicant should have excellentwritten and verbal communication skills in English, ability to workindependently and collaboratively with graduate students and otherpostdoctoral fellows, plan and perform experiments, analyze data,communicate results in scientific publications, and enjoy learning newtechniques. Previous experience in supervising students, guidingresearch projects, contributing to grant applications, and preparingeffective graphics are advantageous. A competitive salary will beoffered for applicants with advanced qualifications; this position couldalso be conceived long-term as a lab manager.
Contact
Interested candidates should send a cover letter, resume, and the namesand contact information (affiliation, mailing address, e-mail, and phonenumber) of three professional references preferably via e-mail toMichael Mayer (mimayer@umich.edu)
The University of Michigan is a premier research institution. TheDepartments of Biomedical Engineering and of Chemical Engineering haveleading programs in the country within a stimulating, multidisciplinary,and collaborative research environment. The Biomembrane Lab is housed inthe newly-constructed Lurie Biomedical Engineering Building withstate-of-the-art facilities and brand new research equipment.
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