法国居里大学肌肉和肌肉疾病研究博士后岗位
Institution
Inserm UMR 538 University Pierre et Marie Curie (http://www.institut-myologie.org)
Position
Post-Doctoral Position
Location
Paris France
Date Posted
Oct 3th 2007
Closing date
Oct 30th 2007
Description
*Website*:
http://www.institut-myologie.org
The Institute of Myology was created in 1996 as a novel structure where medical doctors of different disciplines and researchers were grouped around the patients with neuromuscular disease. This idea of public-private partnership was initiated by the French Muscular Dystrophy Association -(Association Froncoise contre les Myopothies - AFM) and was endorsed by the University Pierre et Marie Curie (Paris VI), the Hospital of the Pitie-Salpêtrière (AP-HP), the Inserm, the CNRS and the CEA. Thomas Voit is its Medical and Scientific Director since 2006.
The main objective was to create a *translational centre of expertise on muscle research and muscle disease*-from fundamental research to patient care- by providing cutting edge research, high clinical expertise, teaching of Myology and performing technical platforms. The Institute has since developed into the largest *French Neuromuscular Reference Centre* with more than 5.000 patients per year. It proposes a global approach to the patients and their families including diagnosis, treatment, genetic counselling, and regular follow-up in an interdisciplinary setting. The Institute is also a first class research structure (around 200 persons involved) which facilitates translational research from the bench to the bed of patient:
*Two research units* conduct programs on myogenesis, muscle genetics, physiopathology, and gene and/or cell therapy;
*The NMR Laboratory and the Neuromuscular Physiology and Evaluation Laboratory* develop methodologies and tools to improve means dedicated to muscle evaluation;
*The Morphology Unit* provides identification and morphological characterisation of paediatric and adult neuromuscular disease;
*The Tissue Bank for Research*, member of Eurobiobank, allows easy access to large tissue collections for research purposes. All the teams of the Institute are involved in development and/or implementation of preclinical and clinical trials and the Institute is *dedicated to the development of innovative modes of therapy, including enzyme replacement, cell and gene biotherapies, for neuromuscular disease.* This includes preclinical studies in the large animal. The clinical protocols also cover natural history studies and Phase I, II and III pharmacotherapy trials. Teaching activities include information, training, and doctoral schools intended for all disciplines interacting with Myology, and offers an inter-university diploma in Myology. The objective is to encourage dissemination of knowledge about striated muscle and its diseases and thus to contribute to the recognition of Myology in the medical and scientific field. The Institute offers medical and research positions -from several months to years- to foster cross-fertilization with other national and international centres.
The Laboratory Traffic and signalisation in epithelial cells (Trafic et signalisation dons les cellules épithéliales, INSERM UMR 538 University Pierre et Marie Curie), Paris, France, invites applications for a_ *Post-doctoral position Peptide-membrane interactions (one or two years)
* The successful candidate will participate in a research program on the investigation of the molecular relationship between peptides and lipid membranes. This research program concerns cell penetrating peptides and antibacterian peptides. The research is the core of an ANR-PCV program grant of Prof. Germain Trugnan that aims to define the role of lipid organization within membrane microdomains on the penetration of peptide vectors and on the action of antimicrobial peptides. The research approach encompasses a powerful combination of biochemical, biophysical and molecular approaches.
*The candidate* will be enthusiastic with a background in physicochemical disciplines. The candidate should have a Ph.D. degree or equivalent. A comprehensive knowledge of membrane cell biology is appreciated and affinity with biophysical methods is an advantage.
*We offer* an experienced, collaborative and international group of colleagues and an excellent infrastructure. We take part of a consortium (and a future Institute) of multidisciplinary research and are engaged in many collaborations. This ensures a wide spectrum of research approaches and facilities. The salary will be in accordance with the French salary scales for academics.
Contact
Additional information can be obtained by e-mail (Germain Trugnan:* Tugnan@ccr.jussieu.fr *and Jesus Ayala-Sanmartin:* jayala@chusa.jussieu.fr). and visiting http://perso.orange.fr/groupe.nj.conte
*Applicants should send their application and CV including 2 references to G. Trugnan orJ. Ayala-Sanmartin. Support letters are welcome.* Mailing address: INSERM U538, Trafic et signalisation dans les cellules épithéliales, CHU Saint Antoine, 27 rue Chaligny, 75012 France. Tel: 33+1 40 01 13 23 and 24; Fax: 33+1 40 01 13 90.