康乃尔大学医学院微生物和免疫学研究博士后岗位

Institution

Medical College of Cornell University
Department of Microbiology and Immunology
New York, NY

Position

Postdoctoral position in biosynthesis and inhibition of small-molecule virulence factors of Mycobacterium species 

Date Posted

Sep 21 2007 

Application Deadline

Open Until Filled 

Job Description

The position is available to join ongoing efforts aimed at investigating the biosynthesis of bioactive polyketides and non-ribosomal peptide virulence factors from Mycobacterium species and developing inhibitors of these and other pathways of these pathogens. Some of our publications related to these efforts are listed below. Candidates must have: (i) a Ph.D. in Biochemistry or a related field; (ii) experience in protein purification/enzymology, and (iii) at least one article as first author published in an international journal.

• Cisar, Ferreras, Soni, Quadri, and Tan (2007). Exploiting ligand conformation in the selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. J. Am. Chem. Soc. 129:7752-53

• Ferreras, Ryu, Di Lello, Tan, and Quadri (2005). Small molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nature Chem. Biol. 1:29-32.

• Onwueme, Vos, Zurita, Ferreras, and Quadri (2005). The dimycocerosate ester polyketide virulence factors of mycobacteria. Prog. Lipid Res. 44:259-302.

• Onwueme, Vos, Zurita, Soll, and Quadri (2005). Identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factors. J. Bacteriol. 187:4760-66.

• Quadri and Ratledge (2005). Iron metabolism in the tubercle bacillus and other mycobacteria. In Tuberculosis and the Tubercle Bacillus. Eds: DN McMurray, K Eisenach, B Gicquel and WR Jacobs, Jr. ASM Press, Washington, DC. p. 341-57.

• Onwueme, Ferreras, Buglino, Lima, and Quadri (2004). Mycobacterial polyketide associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5. PNAS 101:4608-13.

Contact

Luis Quadri, Ph.D.
Microbiology and Immunology
New York, NY
United States
Email: leq2001@med.cornell.edu 
Employer's Web Site:  http://www.med.cornell.edu/research/lequadri/publications.html

Only candidates currently in the U.S. are being considered at this time.