波士顿Tufts-新英格兰医学研究中心肿瘤生物学研究博士后岗位

Institution

Tufts-New England Medical Center

Position

Post Doctoral Fellow

Location

Boston, MA

Date Posted

Sep 12th 2007

Application Deadline

Open Until Filled 

Description

We have an opening for a Post-doctoral Fellow to work in the field of Cancer Biology and Angiogenesis in the Laboratory of Hemostasis and Thrombosis within the Molecular Oncology Research Institute at Tufts-New England Medical Center.

Emerging evidence suggests that matrix metalloproteases (MMPs) play a pivotal role in vascular integrity and wound healing, however, inappropriate MMP activity may underlie the pathogenesis of several diseases including cancer. Controlling MMP activity in these diseases may be a valid target for therapy. We recently made the observation that tumor derived angiogenic factor Cyr61 modulates MMP production on stromal cells.

Both Cyr61 and invasogenic factors such as MMPs and angiogenic factors are highly upregulated by several cell types in the context of tumor blood vessel formation and development. However, it is completely unknown what role(s), Cyr61 or its proteolytic fragments have in signaling and how they regulate either normal blood vessel biology or (patho)physiologic tumor blood vessel development.

The post-doctoral fellow will investigate the molecular mechanism and (patho)physiologic relevance of Cyr61 signaling in breast cancer cells and stromal cells (endothelia and fibroblasts) and study its role in orchestration of blood vessel development in the context of breast tumors. Furthermore, role of breast cancer derived Cyr61 in bone metastasis will be examined.

SKILLS REQUIRED:

The position requires excellent quantitative and analytical skills and experience with tissue culture techniques. Applicants with a very strong background in biochemistry/cell biology and angiogenesis are preferred but not essential.

Please send your CV to Lidija Covic, lcovic@tufts-nemc.org  

Contact

Lidija Covic
Molecular Oncology Research Institute
Tufts-New England Medical Center
750 Washington St. Box 7510
Boston, MA 02111
United States
Phone: 617-636-4665
Fax: 617-636-7855
Email: lcovic@tufts-nemc.org 
Employer's Web Site:  http://www.tufts-mori.org/investigators/investigators.asp