Senior Scientist, Protein Structure and Design

Division: Roche Innovation Center Shanghai (This position belongs toShangha******** Pharmaceuticals Ltd.)
Location: Shanghai
Working Year******** 5 years or above
Degree: PhD
Recruiter's Email: ********

Description:
The Chemical Biology Department is part of Therapeutic Modalities (TMo)within Roche Pharma Research an******** Development (pRED). We deliverleading edge science to drive the success of Roche’s early pipelinediscovery research activities through strong expertise in highthroughput or focuse******** platforms, DNA encode******** technology,translational protein science & enzymology/b******** phenotypiccell-base******** an******** cell platforms, biostructure determinationan******** assiste******** discovery. Our breadth of capabilitiesfurther enable or drive innovative approaches across small, mediuman******** molecule therapeutic & drug delivery modalities.

Senior scientist in Protein Structure an******** Group in ChemicalBiology Department at Roche Innovation Center Shanghai. We are seeking amotivate******** in the area of protein sc******** including biochemicalan******** methods. You will play key roles in target val******** hit******** hit validation an******** study in drug discovery process. Yourresponsibilities are some of following field********
1. Des******** expre********, an******** proteins of therapeuticinterest
2. Perform SPR an******** experiments to characterize protein-l********protein-prote******** protein-nucleic ac********
3. Design critical enzymatic assays to address mechanistic questionsan******** hit qualification
4. Translate in vitro enzymatic activity to cellular activity to driveSAR exploration.

Qualification********
1. You shoul******** PhD in protein chem******** b******** enzymology orbiophysics with at least 5 years of drug discovery experience.Experience in pharmaceutical or biotech company is preferred.
2. Excellent publication an******** track record.
3. Sol******** an******** in expression vector construct********multiple protein expression systems an******** purification techniques.
4. Expertise in biophysical techniques including SEC-MALS, SPR, ITCan********, etc.
5. A goo******** in developing enzymatic assays including enzyme kinetican******** mechanisms or deep understanding on protein LCMS techniquesis plus.
6. Excellent presentat******** writing an******** skills among teammembers.
7. Experience preferre******** program leadershi******** high levelskills leading a drug discovery program to success, leveraging know-how& accountabilities from areas outside your own area of expertisean********.
8. Experience working in new ******** building new platforms or bringingin new method******** in protein science.