生命科学与技术学院刘冀珑研究组招聘副研究员、助理研究员和博士后

Long-term positions in Professor Ji-Long Liu’s Group at ShanghaiTechUniversity

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Research Associate Professor
Research Assistant Professor
Postdoctoral Fellow


Biology of the cytoophidium: an interdisciplinary approach


Professor Ji-Long Liu is relocating his research group from theUniversity of Oxfor******** ShanghaiTech Un******** a newlyestablishe******** university locate******** Zhang-Jiang High-Tech Parkin Pu******** Shanghai, the “Pharma Valley” of China. We are looking forfour motivate******** enthusiastic scientists to join Professor Ji-LongLiu’s research group in Shanghai.


The cytoophidium (plural “cytoophidia”), meaning the cellular snake inGreek, represents a novel type of organelles. In 2010, three groupsincluding us discovere******** CTP synthase is compartmentalise********the cytoophidium. Cytoophidia have existe******** our planet for atleast 3 billion years an******** evolutionarily conserve********bacteria to human. Using the fruitfly Drosophila melanogaster, thefission yeast Schizosaccharomyces pombe an******** cells as prime modelsystems, we will study the mechanisms by which metabolic enzymes such asCTP synthase an******** dehydrogenase are compartmentalise******** acell. CTP synthase an******** dehydrogenase have been attractive targetsfor developing agents against cancer, virus an********. We willinvestigate how various metabolic enzymes are assemble********cytoophidia an******** the cytoophidium an******** kin********linke******** metabolic regulation an******** biology.


The post holders will join a highly interactive research team working onmetabolic cell biology. You will develop genetic an******** approachesto study the biology of the cytoophidium in fruitfly or fission yeast.The study of metabolic compartmentation by genetic an******** approachespromises to form a broa******** on basic cellular ******** as well assheds light on molecular mechanism of disease relate********intracellular compartments.


The successful applicant shoul******** a strong backgroun********genet******** biochemistry an******** biology. Experience of Drosophilaor yeast genetics woul******** an a******** although training will begiven. Excellent organisational an******** skills will be re********together with the ability to work well within a team.




You will work in the School of Life Science an******** (SLST) atShanghaiTech University. SLST aims to develop into a world-class,research-oriente******** in life science an********. Additionalinformation about my new lab at Shangha******** click here. My pastresearch at Oxford, click here. Informal enquiries can be made toProfessor Ji-Long Liu at ********


These posts are available from 11 July 2016. They provide opportunitiesto develop research project skills an******** collaborative links withcolleagues within the ShanghaiTech University an********.


Application Procedure: Submit a cover letter containing the descriptionof the major research ach******** a CV an******** names an******** ofthree individuals who can serve as references to ********, cc to********
Review of applications is on a rolling basis with no ******** until allthe positions are filled.


Selective References
1. Liu JL. (2016). The cytoophidium an******** kind: Filamentationan******** of metabolic enzymes. Annual Review of Cell an********B******** 32 Epub 27 June 2016. (DOI:10.1146/annurev-cellbio-111315-124907 )
2. Aughey GN, Grice SJ an******** JL. (2016). The interplay between MYCan******** synthase in Drosophila. PLOS Genetics 12(2):e********.
3. Ghosh S, Tibbit C an******** JL. (2016). Effective knockdown ofDrosophila long non-coding RNAs by CRISPR interference. Nucleic AcidsResearch 44(9):e84
4. Bassett AR, Tibbit C, Ponting CP an******** JL. (2013). Highlyefficient targete******** of Drosophila with the CRISPR/Cas9 system.Cell Reports 4(1):220-8.
5. Liu JL. (2010). Intracellular compartmentation of CTP synthase inDrosophila. Journal of Genetics an******** 37(5):281-96.
6. Liu JL, Murphy C, Buszczak M, Clatterbuck S, Goodman R an******** JG.(2006). The Drosophila melanogaster Cajal body. Journal of Cell Biology172(6):875-84.