DMPK

Responsibilities:

• Maintain and develop DMPK platform technology and capability

• Lead DMPK group and work with CROs to design, analyze, reportpharmacokinetic and pharmacodynamics studies and

results to support internal drug discovery projects.

• Be responsible to assess ADME and physicochemical properties ofNCEs, plasma protein binding, permeability, solubility, stability, IVIVEand DDI from early leads, preclinic candidate to clinic drug candidate,at all stages of drug discovery process.

• Join project teams at the early stage to ensure effectiveintegration of pharmacokinetics and accelerate the progress

and facilitate the translational efforts at the later stage.

• Make dose assessment in animal models and humans.

• Be familiar with and suggest for formulation methods and TK studydesign.

• Communicate and represent as a PK expert internally and externally



Qualification:

• Ph.D. or master in Pharmaceutical Sciences, Pharmacology, orrelated field with extensive experience on DMPK/ADMET and bioanalysis,with a specific focus on pharmacokinetics.

• Familiar with exploratory tox, animal studies, and animal doseformulation, as well as in vitro-in vivo extrapolation and thecapability to use PK software for data analysis and modelling is a plus.

• A minimum of 3 years pharmaceutical industry experience in theconduct of pharmacokinetic and pharmacodynamics support.

• Desirable to have experience as a team lead representing DMPKdepartment on interdisciplinary project teams.

• Fluent in English for both writing and presentation