The unit of Clinical and Experimental Immunology at Istituto Clinico Humanitas in Milan, Italy (Dr. Domenico Mavilio; Dr. Enrico Lugli) is currently seeking a highly motivated post-doctoral scientist to study the transcriptional regulation of human T cell and NK cell differentiation. The position is available for 3 years. Salary will be commensurate with experience.
The laboratory currently studies the T and NK cell responses in the blood and human tissues in individuals with cancer treated with chemotherapy or bone marrow transplantation. The group is specialized in the identification and characterization of novel lymphocyte subsets and in the evaluation of their anti-tumor and immune reconstitution potential by using state-of-the-art 18-color polychromatic flow cytometry/cell sorting, cellular technologies and antigen-specific T cell assays. Full access to Humanitas facilies (flow cytometry, confocal and two-photon microscopy, Illumina station, BSL-3, SPF mouse house) will be granted.
The optimal candidate would have a PhD in molecular biology or biochemistry and a strong experience in gene expression and transcriptional regulation, gene transfer, protein expression and interaction with targets, cell culture and mouse manipulation. Previous experience with immunological techniques is preferred but not required.
Applicants should be able to carry out projects independently and expected to work with collaborators within the institute and abroad. Fluent English is required.
To apply, please send an application letter, your CV, and the contact information of three referees to Dr. Enrico Lugli (firstname.lastname@example.org).
1. Fauci, A.S., Mavilio, D., Kottilil, S. NK cells in HIV infection: paradigm for protection or targets for ambush (2005). Nature reviews. Immunology 5, 835-843.
2. K. Hudspeth et al., The role of natural killer cells in autoimmune liver disease: A comprehensive review. Journal of autoimmunity, 46, 55-65.
3. Gattinoni, L., Lugli, E. et al. A human memory T cell subset with stem cell-like properties (2011). Nature medicine 17, 1290-1297.
4. Lugli, E. et al. Superior T memory stem cell persistence supports long-lived T cell memory (2013). J Clin Invest 123, 594-599.
5. Mahnke, Y., Brodie, T., Sallusto, F., Roederer, M. & Lugli, E. The who's who of T cell differentiation: human memory T cell subsets (2013). European journal of immunology 11, 2797-2809…