Postdoctoral Research Scientist
Salary range £28,977 p.a. to £32,196 p.a.
The Babraham Institute is a charity that is world renowned for its life sciences research that seeks to enhance lives and improve wellbeing.
The Cook lab (http://www.babraham.ac.uk/pjl_pages/cook/members.html) study protein kinase signalling pathways and their role in controlling cell proliferation and cell survival. We translate our basic bioscience through interactions with key stakeholders. For this new project we are seeking a Postdoctoral Research Scientist to work on a collaborative project with Prof Duncan Jodrell (CRUK Cambridge Institute) http://www.cambridgecancer.org.uk/research-groups/jodrell-group.
We will investigate how pancreatic cancer cells respond to clinically relevant MEK inhibitors. We want to identify drivers of innate or intrinsic resistance, identify mechanisms of pathway rebound or adaptation and use this information to test rational drug combinations. This work is supported by AstraZeneca and continues a long and fruitful collaborations based on the RAF-MEK1/2-ERK1/2 pathway (Balmanno et al, 2009; Int J Cancer; Little et al, 2011 Science Signalling; Cook & Sale, 2013, Biochem J; Chell et al, 2013 Oncogene; Little et al, 2013 Oncogene).
The successful applicant will have PhD in Biochemistry or Cell Biology (especially experience in the analysis of growth factor signal transduction) and have a good knowledge and practical experience of cancer biology and targeted cancer therapeutics. Key skills a successful candidate must possess include: tumour cell culture; use of targeted therapeutics; analysis of signal pathway activation by western blot or immune fluorescence; analysis of cell cycle and cell death by flow cytometry and RNAi. Skills in gene expression analysis by Q-RTPCR and/or microarray and immunohistochemistry are also highly desirable. This is a fixed term position and is available for 2 years
The successful applicant will join an interactive, multidisciplinary team in the Signalling Programmehttp://www.babraham.ac.uk/signalling/index.html at the Babraham Institute. Informal enquiries may be made to Dr. Simon Cook email@example.com. Further information about the Institute can be found on our website. The applicant will also spend time in Prof Duncan Jodrell’s lab.
Application forms and further details are available electronically from our website (www.babraham.ac.uk), or by contacting our 24-hour Recruitment Line on 01223 496365, or e-mail:firstname.lastname@example.org. On applying please quote reference SC/PD/LT. Closing date for completed applications is Wednesday 18th September 2013. NO AGENCIES PLEASE
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