蒙特利尔临床研究所免疫相关蛋白研究博士后岗位
来源：丁香人才网
日期：2007-11-22
Institution
Institut de recherches cliniques de Montreal - IRCM
Position
Post-doctoral research fellow
Location
Montreal, Canada
Date Posted
Nov 21th 2007
Description
The laboratory "Hematopoiesis and Cancer" at the Institut deRecherches Cliniques de Montreal (IRCM) seeks a highly motivatedpost-doctoral researcher at a junior or senior level to work ondeciphering the function of alternative splicing in the immune system.
Of interest to us are in particular the role of the proteins U2AF26, thetranscription factor and chromatin modifier Gfi1 and the protein hnRNPLthat all impinge on the alternative splicing of the gene encoding CD45.
The questions to be solved would be which role these factors play in thedevelopment and activation of immune cells, in particular memoryT-cells, and which target genes are regulated by these factors. Theproject involves using transgenic and gene deficient mice alreadyavailable in the laboratory that over express or lack the genes encodingthese factors.
References:
Heyd et al., Nature Immunology, 2006
Vassen et al., EMBO Journal, 2006
Heyd and Moroy, RNA, 2007
Requirements:
Applicants should have a PhD degree in relevant fields of biochemistrymolecular biology and/or immunology and enthusiasm and motivation forbasic biomedical research. Also essential is a strong interest in theregulation of gene expression and alternative splicing in thehematopoietic and immune system. A previous experience with transgenicand knockout mice would be desirable. Good communication skills inEnglish are a prerequisite.
Interested applicants should send a cover letter explaining theirinterests in the project, a curriculum vitae including previouspublications and names of three references per Email.
Contact
Information about the IRCM at http://www.ircm.qc.ca/en. Information onour research unit "Hematopoiesis and Cancer" at our website: http://www.ircm.qc.ca/en/recherche/statique/unite45.html
Institut de recherches cliniques de Montreal - IRCM
Position
Post-doctoral research fellow
Location
Montreal, Canada
Date Posted
Nov 21th 2007
Description
The laboratory "Hematopoiesis and Cancer" at the Institut deRecherches Cliniques de Montreal (IRCM) seeks a highly motivatedpost-doctoral researcher at a junior or senior level to work ondeciphering the function of alternative splicing in the immune system.
Of interest to us are in particular the role of the proteins U2AF26, thetranscription factor and chromatin modifier Gfi1 and the protein hnRNPLthat all impinge on the alternative splicing of the gene encoding CD45.
The questions to be solved would be which role these factors play in thedevelopment and activation of immune cells, in particular memoryT-cells, and which target genes are regulated by these factors. Theproject involves using transgenic and gene deficient mice alreadyavailable in the laboratory that over express or lack the genes encodingthese factors.
References:
Heyd et al., Nature Immunology, 2006
Vassen et al., EMBO Journal, 2006
Heyd and Moroy, RNA, 2007
Requirements:
Applicants should have a PhD degree in relevant fields of biochemistrymolecular biology and/or immunology and enthusiasm and motivation forbasic biomedical research. Also essential is a strong interest in theregulation of gene expression and alternative splicing in thehematopoietic and immune system. A previous experience with transgenicand knockout mice would be desirable. Good communication skills inEnglish are a prerequisite.
Interested applicants should send a cover letter explaining theirinterests in the project, a curriculum vitae including previouspublications and names of three references per Email.
Contact
Information about the IRCM at http://www.ircm.qc.ca/en. Information onour research unit "Hematopoiesis and Cancer" at our website: http://www.ircm.qc.ca/en/recherche/statique/unite45.html
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