资讯分类

爱丁堡大学生物医学工程博士后岗位

日期:2007-10-25
Institution

University of Edinburgh (http://www.see.ed.ac.uk/becom...)

Position

Postdoctoral Research Fellow

Location

Edinburgh, UK

Date Posted

Oct 24th 2007

Closing Date

Dec 1st 2007

Salary

£27,466 – £32,796

Description

Chemical imaging for biomedicine by Coherent Anti-Stokes RamanSpectroscopy (CARS)

Biomedical Engineering, University of Edinburgh

Optical microscopy is one of the most widely applied scientific tools,but in biology usually requires a fluorescent agent to give chemicalcontrast. Raman spectroscopy gives chemical information in opticalmicroscopy, as each molecule has a specific vibrational spectrum.However, for molecular species this Raman signal is extremely weak, soimages take many hours to acquire and contrast is poor. CARS is a newvariant of Raman spectroscopy using two lasers to excite molecules, andis 5 orders of magnitude more efficient – so images are acquired inseconds. The system has been installed and has produced CARS images, andis now ready to apply to biomedical imaging.

The successful candidate will optimize the imaging conditions for livecells and tissue, and apply the technique to solve important biologicalproblems – leading to high impact publications. The confocal system alsoincorporates an atomic force microscope, so chemical imaging can beperformed at 10 nm resolution. The microscope also acquiresfluorescence, FLIM, SHG and DIC images.

The candidate should have a track record of advanced optical imaging inbiology, so expertise in SHG, FLIM, multi-photon, Raman or CARS imagingis essential. Experience with atomic force microscopy or pulsed lasersystems, is useful but not essential.

The opportunity to undertake international travel to collaboratinginstitutes and for conference presentations will be available.

Contact

Informal Enquiries to: Dr Alistair Elfick (tel : +44 (0)131 650 7254,email : Alistair.Elfick@ed.ac.uk)

Details of our research can be found at :
http://www.see.ed.ac.uk/becomin/CARS.htm

More details about the CARS microscope are available on request from DrAndy Downes (tel: +44 (0)131 650 8554, email : Andy.Downes@ed.ac.uk)

For further particulars and an application pack visit our website(http://www.jobs.ed.ac.uk/) or telephone the recruitment line on +44(0)131 650 2511.
[作者:jurgen    编辑:]